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Article

Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.

Molecular and cellular biology - 1 Aug 2005

Fang Xiangdong, Sun Jin, Xiang Ping, Yu Man, Navas Patrick A, Peterson Kenneth R, Stamatoyannopoulos George, Li Qiliang

Abstract excerpt

Deletion of the 234-bp core element of the DNase I hypersensitive site 3 (5'HS3) of the locus control region (LCR) in the context of a human beta-globin locus yeast artificial chromosome (beta-YAC) results in profound effects on globin gene expression in transgenic mice. In contrast, deletion of a 2.3-kb 5'HS3 region, which includes the 234-bp core sequence, has a much milder phenotype. Here we report the effects...

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Identifiers

PMID: 16055715
DOI: 10.1128/MCB.25.16.7033-7041.2005
PMCID: PMC1190234

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Source receipt: pubmed, retrieved 7 Sept 2026.

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