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Article

Conserved E Boxes Function as Part of the Enhancer in Hypersensitive Site 2 of the β-Globin Locus Control Region

1 Jan 1997

Abstract excerpt

The human beta-globin gene cluster is regulated in part by a distal locus control region that is required for opening a chromatin domain in erythroid cells and enhancing expression of the beta-like globin genes at the correct developmental stages. One part of the locus control region, called hypersensitive site 2 (HS2), functions as a strong enhancer. Matches to the consensus binding sites for basic...

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PMID: 8995271
DOI: 10.1074/jbc.272.1.369

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Research trail→

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Conserved E Boxes Function as Part of the Enhancer in Hypersensitive Site 2 of the β-Globin Locus Control RegionPMID 8995271Read ↗

DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice.Semantic proximity Read ↗

The role of transcriptional activator GATA-1 at human beta-globin HS2.Semantic proximity Read ↗

Structural and functional cross-talk between a distant enhancer and the epsilon-globin gene promoter shows interdependence of the two elements in chromatin.Semantic proximity Read ↗

Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression.Semantic proximity Read ↗

Deletion of a negatively acting sequence in a chimeric GATA-1 enhancer-long terminal repeat greatly increases retrovirally mediated erythroid expression.Semantic proximity Read ↗

Nucleotide variation regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region.Semantic proximity Read ↗

The GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgene.Semantic proximity Read ↗

DNA G-quadruplex structures act as functional elements in α- and β-globin enhancersSemantic proximity Read ↗

Reconstitution of Human β-Globin Locus Control Region Hypersensitive Sites in the Absence of Chromatin AssemblySemantic proximity Read ↗

Conserved elements containing NF-E2 and tandem GATA binding sites are required for erythroid-specific chromatin structure reorganization within the human beta-globin locus control region.Semantic proximity Read ↗

Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression.Semantic proximity Read ↗

Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Semantic proximity Read ↗

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