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Article

Deletion of a negatively acting sequence in a chimeric GATA-1 enhancer-long terminal repeat greatly increases retrovirally mediated erythroid expression.

The Journal of biological chemistry - 12 Mar 2004

Testa Anna, Lotti Francesco, Cairns Linda, Grande Alexis, Ottolenghi Sergio, Ferrari Giuliana, Ronchi Antonella

Abstract excerpt

The locus control region of the beta-globin gene cluster has been used previously to direct erythroid expression of globin genes from retroviral vectors for the purpose of gene therapy. Short erythroid regulatory elements represent a potentially valuable alternative to the locus control region. Among them, the GATA-1 enhancer HS2 was used to replace the retroviral enhancer within the 3'-long terminal repeat (LTR)...

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Source

Identifiers

PMID: 14701820
DOI: 10.1074/jbc.M313638200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of a negatively acting sequence in a chimeric GATA-1 enhancer-long terminal repeat greatly increases retrovirally mediated erythroid expression.PMID 14701820Read ↗

The GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgene.Semantic proximity Read ↗

DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice.Semantic proximity Read ↗

Conserved E Boxes Function as Part of the Enhancer in Hypersensitive Site 2 of the β-Globin Locus Control RegionSemantic proximity Read ↗

Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression.Semantic proximity Read ↗

A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1.Semantic proximity Read ↗

Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene.Semantic proximity Read ↗

Large-scale discovery of potent, compact and lineage specific enhancers for gene therapy vectorsSemantic proximity Read ↗

In vivo analysis of retroviral enhancer mutations in hematopoietic cells: SP1/EGR1 and ETS/GATA motifs contribute to long terminal repeat specificity.Semantic proximity Read ↗

An insulator with barrier-element activity promotes α-spectrin gene expression in erythroid cellsSemantic proximity Read ↗

Transactivation of the GATA-1 promoter by a myb-ets-containing mouse retrovirus is mediated by CACCC elements.Semantic proximity Read ↗

3'HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression.Semantic proximity Read ↗

The human elongation factor 1 alpha (EF-1α) first intron highly enhances expression of foreign genes from the murine cytomegalovirus promoterSemantic proximity Read ↗

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