Article
Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression.
Nucleic acids research - 25 Jun 1994
Caterina J J, Donze D, Sun C W, Ciavatta D J, Townes T M
Abstract excerpt
DNase I hypersensitive site 2 (HS 2) of the human beta-globin Locus Control Region (LCR) directs high level expression of the beta-globin gene located 50 kilobases downstream. Experiments in cultured cells and in transgenic mice demonstrate that duplicated AP1-like sites in HS 2 are required for...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cloning, Molecular
- DNA
- DNA-Binding Proteins
- Erythrocytes
- Erythroid-Specific DNA-Binding Factors
- Gene Expression Regulation
- Globins
- HeLa Cells
- Humans
- Leukemia, Erythroblastic, Acute
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- NF-E2 Transcription Factor