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Article

Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions.

Human genetics - 1 Sept 2014

Li Xuelin, Price Matthew A, He Dongning, Kamali Anatoli, Karita Etienne, Lakhi Shabir, Sanders Eduard J, Anzala Omu, Amornkul Pauli N, Allen Susan, Hunter Eric, Kaslow Richard A, Gilmour Jill, Tang Jianming

Abstract excerpt

Research in the past two decades has generated unequivocal evidence that host genetic variations substantially account for the heterogeneous outcomes following human immunodeficiency virus type 1 (HIV-1) infection. In particular, genes encoding human leukocyte antigens (HLA) have various alleles, haplotypes, or specific motifs that can dictate the set-point (a relatively steady state) of plasma viral load (VL),...

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Identifiers

PMID: 24969460
DOI: 10.1007/s00439-014-1465-x
PMCID: PMC4127002

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