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Article

Unique leptin trafficking by a tailless receptor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2010

Tu Hong, Hsuchou Hung, Kastin Abba J, Wu Xiaojun, Pan Weihong

Abstract excerpt

Impairment in blood-to-brain transport of leptin is a major cause as well as consequence of obesity. Leptin crosses the blood-brain barrier by transcytosis rather than undergoing intracellular degradation. Results from previous studies have indicated that the membrane juxtapositional cytoplasmic sequence of the leptin receptor ObR is responsible for leptin transport. To identify the specific structural domains,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20223942
DOI: 10.1096/fj.09-143487
PMCID: PMC2887260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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