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Article

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.

Diabetes - 1 Feb 1999

Uotani S, Bjørbaek C, Tornøe J, Flier J S

Abstract excerpt

Long (ObRb) and short (ObRa) leptin receptor isoforms are thought to play essential roles in mediating leptin signaling and the transport and degradation of leptin, respectively. Although the capacity of these cloned receptor species to mediate signal transduction has been reported, there is no information on the ability of individual receptor species to mediate leptin internalization and degradation or to...

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Identifiers

PMID: 10334302
DOI: 10.2337/diabetes.48.2.279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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