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Article

Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway.

The Journal of biological chemistry - 20 May 2011

Séron Karin, Couturier Cyril, Belouzard Sandrine, Bacart Johan, Monté Didier, Corset Laetitia, Bocquet Olivier, Dam Julie, Vauthier Virginie, Lecœur Cécile, Bailleul Bernard, Hoflack Bernard, Froguel Philippe, Jockers Ralf, Rouillé Yves

Abstract excerpt

Endospanin-1 is a negative regulator of the cell surface expression of leptin receptor (OB-R), and endospanin-2 is a homologue of unknown function. We investigated the mechanism for endospanin-1 action in regulating OB-R cell surface expression. Here we show that endospanin-1 and -2 are small integral membrane proteins that localize in endosomes and the trans-Golgi network. Antibody uptake experiments showed that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21454707
DOI: 10.1074/jbc.M111.224857
PMCID: PMC3093871

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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