Article
Mechanism of receptor assembly via the pleiotropic adipokine Leptin
2022-12-01
Abstract excerpt
The adipokine Leptin activates its type I cytokine receptor (LEP-R) in the hypothalamus to regulate body weight and exerts additional pleiotropic functions in immunity, fertility, and cancer. However, the structure and mechanism of Leptin-mediated LEP-R assemblies has remained unclear. Here, we show that Leptin:LEP-R assemblies adopt an unprecedented structure within the type I cytokine receptor family featuring 3...
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Identifiers and source
- Literature Corpus work
- f216bec1-6330-58ce-a19f-d1c34e4a48f4
- DOI
- 10.1101/2022.12.01.518327