Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies.

The Journal of biological chemistry - 1 Aug 2024

Baird Harry J M, Shun-Shion Amber S, Mendes de Oliveira Edson, Stalder Danièle, Liang Lu, Eden Jessica, Chambers Joseph E, Farooqi I Sadaf, Gershlick David C, Fazakerley Daniel J

Abstract excerpt

The hormone leptin, primarily secreted by adipocytes, plays a crucial role in regulating whole-body energy homeostasis. Homozygous loss-of-function mutations in the leptin gene (LEP) cause hyperphagia and severe obesity, primarily through alterations in leptin's affinity for its receptor or changes in serum leptin concentrations. Although serum concentrations are influenced by various factors (e.g., gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HEK293 Cells
Share to Leptin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Obesity

Share to Proteasome Endopeptidase Complex

Share to Receptors, Leptin

Share to Secretory Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 39002670
DOI: 10.1016/j.jbc.2024.107562
PMCID: PMC11366920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies.PMID 39002670Read ↗

A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficienciesSemantic proximity Read ↗

A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review.Semantic proximity Read ↗

Mechanism of receptor assembly via the pleiotropic adipokine LeptinSemantic proximity Read ↗

Prevalence Estimates of Putatively Pathogenic Leptin Variants in the gnomAD DatabaseSemantic proximity Read ↗

Monogenic forms of childhood obesity due to mutations in the leptin geneSemantic proximity Read ↗

Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe ObesitySemantic proximity Read ↗

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.Semantic proximity Read ↗

Uncovering the molecular mechanisms behind disease-associated leptin variants.Semantic proximity Read ↗

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levelsSemantic proximity Read ↗

Identification of a novel leptin receptor (LEPR) variant and proof of functional relevance directing treatment decisions in patients with morbid obesity.Semantic proximity Read ↗

SULT1A1/SULT1E1-Mediated Adipokine Hypersulfation and Insulin Trapping: Defining a Sulfur Flux Subtype in the Pathogenesis of Pre-DiabetesSemantic proximity Read ↗

Structure, production and signaling of leptin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.