Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB.

Peptides - 1 Jul 2011

Hsuchou Hung, Kastin Abba J, Tu Hong, Markadakis Emily N, Stone Kirsten P, Wang Yuping, Heymsfield Steven B, Chua Streamson S, Obici Silvana, Magrisso I Jack, Pan Weihong

Abstract excerpt

The functions of leptin receptors (LRs) are cell-type specific. At the blood-brain barrier, LRs mediate leptin transport that is essential for its CNS actions, and both endothelial and astrocytic LRs may be involved. To test this, we generated endothelia specific LR knockout (ELKO) and astrocyte specific LR knockout (ALKO) mice. ELKO mice were derived from a cross of Tie2-cre recombinase mice with LR-floxed mice,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Blood-Brain Barrier

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Half-Life

Share to Iodine Radioisotopes

Share to Leptin

Share to Perfusion

Share to Receptors, Leptin

Share to Spinal Cord

Source

Open in PubMed Open full text

Identifiers

PMID: 21616110
DOI: 10.1016/j.peptides.2011.05.011
PMCID: PMC3137692

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB.PMID 21616110Read ↗

Unique leptin trafficking by a tailless receptor.Semantic proximity Read ↗

Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity.Semantic proximity Read ↗

Tanycyte-Independent Control of Hypothalamic Leptin SignalingSemantic proximity Read ↗

Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity.Semantic proximity Read ↗

Astrocytic β1-integrin affects cellular composition of murine blood brain barrier in the cerebral cortex.Semantic proximity Read ↗

Nuclear receptor ligand screening in an iPSC-derived <i>in vitro</i> blood-brain barrier model identifies new contributors to leptin transportSemantic proximity Read ↗

Is Obesity a Disease of the Blood-Brain Barrier? Physiological, Pathological, and Evolutionary ConsiderationsSemantic proximity Read ↗

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.Semantic proximity Read ↗

The Effects of Leptin Replacement on Neural Plasticity.Semantic proximity Read ↗

Obesity induces functional astrocytic leptin receptors in hypothalamus.Semantic proximity Read ↗

Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types.Semantic proximity Read ↗

Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.