Article
Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat.
Endocrinology - 1 Sept 1998
da Silva B A, Bjørbaek C, Uotani S, Flier J S
Abstract excerpt
Mutations of the leptin receptor have been found to cause obesity in rodents. The fa mutation that is responsible for obesity in Zucker rats is a missense mutation (269 gln-->pro) in the extracellular domain of the leptin receptor. We have characterized the effects of this mutation on the two maj...
Topics
- Amino Acid Sequence
- Animals
- Binding, Competitive
- CHO Cells
- Carrier Proteins
- Cricetinae
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Humans
- Immediate-Early Proteins
- Isomerism
- Janus Kinase 2
- Leptin
- Mice
- Mutation
- Obesity
- Oxidation-Reduction
- Phosphorylation