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Article

Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat.

Endocrinology - 1 Sept 1998

da Silva B A, Bjørbaek C, Uotani S, Flier J S

Abstract excerpt

Mutations of the leptin receptor have been found to cause obesity in rodents. The fa mutation that is responsible for obesity in Zucker rats is a missense mutation (269 gln-->pro) in the extracellular domain of the leptin receptor. We have characterized the effects of this mutation on the two major isoforms of the leptin receptor, Ob-Rb and Ob-Ra, by studying cell-surface expression, leptin binding affinity,...

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Identifiers

PMID: 9724018
DOI: 10.1210/endo.139.9.6168

Genes

JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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