Article
Constitutive and impaired signaling of leptin receptors containing the Gln --> Pro extracellular domain fatty mutation.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 1997
White D W, Wang D W, Chua S C, Morgenstern J P, Leibel R L, Baumann H, Tartaglia L A
Abstract excerpt
Leptin (OB), an adipocyte-secreted circulating hormone, and its receptor (OB-R) are key components of an endocrine loop that regulates mammalian body weight. In this report we have analyzed signal transduction activities of OB-R containing the fatty mutation [OB-R(fa)], a single amino acid substitution at position 269 (Gln --> Pro) in the OB-R extracellular domain that results in the obese phenotype of the fatty...
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