Article
Obesity-linked variants of melanocortin-4 receptor are misfolded in the endoplasmic reticulum and can be rescued to the cell surface by a chemical chaperone.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 2010
Granell Susana, Mohammad Sameer, Ramanagoudr-Bhojappa Ramanagouda, Baldini Giulia
Abstract excerpt
Melanocortin-4 receptor (MC4R) is a G protein-coupled receptor expressed in the brain where it controls food intake. Many obesity-linked MC4R variants are poorly expressed at the plasma membrane and are retained intracellularly. We have studied the intracellular localization of four obesity-linked MC4R variants, P78L, R165W, I316S, and I317T, in immortalized neurons. We find that these variants are all retained...
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