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Article

Effects of Paraoxonase 1 gene polymorphisms on organophosphate insecticide metabolism in Japanese pest control workers.

Journal of occupational health - 1 Jan 2016

Sato Hirotaka, Ito Yuki, Ueyama Jun, Kano Yuya, Arakawa Tomoya, Gotoh Masahiro, Kondo Takaaki, Sugiura Yuka, Saito Isao, Shibata Eiji, Kamijima Michihiro

Abstract excerpt

OBJECTIVES: Paraoxonase 1 (PON1) in serum detoxifies organophosphate (OP) insecticides by hydrolysis. The present cross-sectional study aimed to clarify the relationship between PON1 single nucleotide polymorphisms (SNPs) and enzyme activities or OP metabolite concentrations in urine of workers occupationally exposed to low-level OPs. METHODS: Among 283 workers in 10 pest control companies located in central...

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Source

Identifiers

PMID: 26549836
DOI: 10.1539/joh.15-0175-OA

Genes

PON1
CPM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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