Article
Importance of HLA-DRB1 and DQA1 genes and of the amino acid polymorphisms in the functional domain of DR beta 1 chain in multiple sclerosis.
Journal of neuroimmunology - 1 Jun 1995
Ghabanbasani M Z, Gu X X, Spaepen M, Vandevyver C, Raus J, Marynen P, Carton H, Cassiman J J
Abstract excerpt
The association of some HLA class II alleles with multiple sclerosis (MS) has been amply documented. In the present study the role of HLA class II haplotypes and genotypes and of polymorphic amino acids at the DR beta 1 locus, located in the antigen binding groove and the CD4 binding domain of th...
Topics
- Adult
- Alleles
- Genes, MHC Class II
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Humans
- Middle Aged
- Multiple Sclerosis
- Polymorphism, Genetic