Article
CIITA gene variants are associated with rheumatoid arthritis in Scandinavian populations.
Genes and immunity - 1 Jul 2012
Eike M C, Skinningsrud B, Ronninger M, Stormyr A, Kvien T K, Joner G, Njølstad P R, Førre O, Flatø B, Alfredsson L, Padyukov L, Undlien D E, Lie B A
Abstract excerpt
Expression of the major autoimmune risk loci DRB1 and DQB1 is regulated by the class II MHC (major histocompatibility complex) transactivator (CIITA), making the CIITA gene a strong autoimmune risk locus candidate. A CIITA promoter single-nucleotide polymorphism (SNP), rs3087456 (-168 A/G), has indeed been associated with several autoimmune diseases, including rheumatoid arthritis (RA). Recently, an intronic SNP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.