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Article

Interaction of HLA-DRB1*1501 allele and TNF-alpha -308 G/A single nucleotide polymorphism in the susceptibility to multiple sclerosis.

Clinical immunology (Orlando, Fla.) - 1 Jun 2011

Shahbazi Majid, Roshandel Danial, Omidnyia Eskandar, Rshaidbaghan Azam

Abstract excerpt

Multiple sclerosis is a multifactorial disorder with complex genetic basis. It is believed that genes encoding HLA molecule and cytokines are involved in the pathogenesis of MS. In this study, we have evaluated the impact of HLA-DRB1*1501 allele and TNF-alpha -308 G/A single nucleotide polymorphism, and their interaction, in the susceptibility to MS in Iranian population. Genomic DNA samples were prepared from...

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Identifiers

PMID: 21396892
DOI: 10.1016/j.clim.2011.02.012

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TNF

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