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Article

A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis.

PloS one - 26 Oct 2010

Field Judith, Browning Sharon R, Johnson Laura J, Danoy Patrick, Varney Michael D, Tait Brian D, Gandhi Kaushal S, Charlesworth Jac C, Heard Robert N, Stewart Graeme J, Kilpatrick Trevor J, Foote Simon J, Bahlo Melanie, Butzkueven Helmut, Wiley James, Booth David R, Taylor Bruce V, Brown Matthew A, Rubio Justin P, Stankovich Jim

Abstract excerpt

We conducted an association study across the human leukocyte antigen (HLA) complex to identify loci associated with multiple sclerosis (MS). Comparing 1927 SNPs in 1618 MS cases and 3413 controls of European ancestry, we identified seven SNPs that were independently associated with MS conditional on the others (each P ≤ 4 x 10(-6)). All associations were significant in an independent replication cohort of 2212...

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Identifiers

PMID: 21049023
DOI: 10.1371/journal.pone.0013454
PMCID: PMC2964313

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