Article
Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2010
Rodríguez-Flores Juan L, Zhang Kuixing, Kang Sun Woo, Wen Gen, Ghosh Sajalendu, Friese Ryan S, Mahata Sushil K, Subramaniam Shankar, Hamilton Bruce A, O'Connor Daniel T
Abstract excerpt
The adrenomedullary hormone epinephrine transduces environmental stressors into cardiovascular events (tachycardia and hypertension). Although the epinephrine biosynthetic enzyme PNMT genetic locus displays both linkage and association to such traits, genetic variation underlying these quantitative phenotypes is not established. Using an integrated suite of computational and experimental approaches, we elucidate...
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