Article
Human dopamine β-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure.
American journal of hypertension - 1 Jan 2011
Chen Yuqing, Zhang Kuixing, Wen Gen, Rao Fangwen, Sanchez Amber P, Wang Lei, Rodriguez-Flores Juan L, Mahata Manjula, Mahata Sushil K, Waalen Jill, Ziegler Michael G, Hamilton Bruce A, O'Connor Daniel T
Abstract excerpt
BACKGROUND: Dopamine β-hydroxylase (DBH) plays an indispensable role in catecholamine synthesis by converting dopamine into norepinephrine. Here, we characterized a DBH promoter polymorphism (C-2073T; rs1989787; minor allele frequency ~16%) that influences not only gene transcription but also enzyme secretion and blood pressure (BP) in vivo. METHODS: Plasma DBH activity was measured spectrophotometrically. DBH...
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