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Article

Human tyrosine hydroxylase natural genetic variation: delineation of functional transcriptional control motifs disrupted in the proximal promoter.

Circulation. Cardiovascular genetics - 1 Apr 2010

Zhang Kuixing, Zhang Lian, Rao Fangwen, Brar Bhawanjit, Rodriguez-Flores Juan L, Taupenot Laurent, O'Connor Daniel T

Abstract excerpt

BACKGROUND: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Common genetic variation at the human TH promoter predicts alterations in autonomic activity and blood pressure, but how such variation influences human traits and, specifically, whether such variation affects transcription are not yet known. METHODS AND RESULTS: Pairwise linkage disequilibrium across the TH locus...

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Identifiers

PMID: 20124442
DOI: 10.1161/CIRCGENETICS.109.904813
PMCID: PMC3064953

Genes

EGR1
SRY
FOXD1

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