Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans.

Clinical pharmacology and therapeutics - 1 Apr 2010

Voora D, Koboldt D C, King C R, Lenzini P A, Eby C S, Porche-Sorbet R, Deych E, Crankshaw M, Milligan P E, McLeod H L, Patel S R, Cavallari L H, Ridker P M, Grice G R, Miller R D, Gage B F

Abstract excerpt

Warfarin demonstrates a wide interindividual variability in response that is mediated partly by variants in cytochrome P450 2C9 (CYP2C9) and vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1). It is not known whether variants in calumenin (CALU) (vitamin K reductase regulator) have an inf...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticoagulants
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Binding Proteins

Share to Dose-Response Relationship, Drug

Share to Mixed Function Oxygenases

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 20200517
DOI: 10.1038/clpt.2009.291
PMCID: PMC2928561

Genes

CALU
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20200517-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans.PMID 20200517Read ↗

Does CALU SNP rs1043550 contribute variability to therapeutic warfarin dosing requirements?Semantic proximity Read ↗

Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.Semantic proximity Read ↗

The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans.Semantic proximity Read ↗

Integrated analysis of genetic variation and gene expression reveals novel variant for increased warfarin dose requirement in African Americans.Semantic proximity Read ↗

Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients.Semantic proximity Read ↗

Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin.Semantic proximity Read ↗

Genetic and clinical predictors of warfarin dose requirements in African Americans.Semantic proximity Read ↗

A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.Semantic proximity Read ↗

A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry.Semantic proximity Read ↗

Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation.Semantic proximity Read ↗

Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European-Americans and Egyptians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.