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Article

Integrated analysis of genetic variation and gene expression reveals novel variant for increased warfarin dose requirement in African Americans.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2017

Hernandez W, Gamazon E R, Aquino-Michaels K, Smithberger E, O'Brien T J, Harralson A F, Tuck M, Barbour A, Cavallari L H, Perera M A

Abstract excerpt

Essentials Genetic variants controlling gene regulation have not been explored in pharmacogenomics. We tested liver expression quantitative trait loci for association with warfarin dose response. A novel predictor for increased warfarin dose response in African Americans was identified. Precision medicine must take into account population-specific variation in gene regulation. SUMMARY: Background Warfarin is...

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Source

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Identifiers

PMID: 28135054
DOI: 10.1111/jth.13639
PMCID: PMC5862636

Genes

VKORC1
CALU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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