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Article

Genetic and clinical predictors of warfarin dose requirements in African Americans.

Clinical pharmacology and therapeutics - 1 Apr 2010

Cavallari L H, Langaee T Y, Momary K M, Shapiro N L, Nutescu E A, Coty W A, Viana M A G, Patel S R, Johnson J A

Abstract excerpt

The objective of this study was to determine whether, in African-American patients, additional vitamin K oxidoreductase complex subunit 1 (VKORC1), cytochrome P450 2C9 (CYP2C9), CYP4F2, or apolipoprotein E (APOE) polymorphisms contribute to variability in the warfarin maintenance dose beyond what is attributable to the CYP2C9*2 and *3 alleles and the VKORC1 -1639G>A genotype. In a cohort of 226 African-American...

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Source

Identifiers

PMID: 20072124
DOI: 10.1038/clpt.2009.223

Genes

VKORC1
APOE

Provenance

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