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Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry.

Blood advances - 22 Oct 2024

Asiimwe Innocent G, Blockman Marc, Cavallari Larisa H, Cohen Karen, Cupido Clint, Dandara Collet, Davis Brittney H, Jacobson Barry, Johnson Julie A, Lamorde Mohammed, Limdi Nita A, Morgan Jennie, Mouton Johannes P, Muyambo Sarudzai, Nakagaayi Doreen, Ndadza Arinao, Okello Emmy, Perera Minoli A, Schapkaitz Elise, Sekaggya-Wiltshire Christine, Semakula Jerome R, Tatz Gayle, Waitt Catriona, Yang Guang, Zhang Eunice J, Jorgensen Andrea L, Pirmohamed Munir

Abstract excerpt

ABSTRACT: Warfarin dose requirements are highly variable because of clinical and genetic factors. Although genetic variants influencing warfarin dose have been identified in European and East Asian populations, more work is needed to identify African-specific genetic variants to help optimize warfarin dosing. We performed genome-wide association studies (GWASs) in 4 African cohorts from Uganda, South Africa, and...

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Identifiers

PMID: 39163621
DOI: 10.1182/bloodadvances.2024014227
PMCID: PMC11493193

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