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Article

Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation.

Journal of medical genetics - 1 Sept 2006

Li T, Lange L A, Li X, Susswein L, Bryant B, Malone R, Lange E M, Huang T-Y, Stafford D W, Evans J P

Abstract excerpt

BACKGROUND: Warfarin is a mainstay of therapy for conditions associated with an increased risk of thromboembolic events. However, the use of this common agent is fraught with complications and little is known regarding inter-individual variation in warfarin response. OBJECTIVE: We tested for association between single nucleotide polymorphisms (SNPs) in VKORC1 and CYP2C9 and average weekly warfarin dose required...

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Share to Anticoagulants
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

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Share to Vitamin K Epoxide Reductases

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Source

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Identifiers

PMID: 16611750
DOI: 10.1136/jmg.2005.040410
PMCID: PMC2564574

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation.PMID 16611750Read ↗

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