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Article

Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European-Americans and Egyptians.

Clinical and translational science - 1 Feb 2016

Hamadeh I S, Shahin M H, Lima S M, Oliveira F, Wilson L, Khalifa S I, Langaee T Y, Cooper-DeHoff R M, Cavallari L H, Johnson J A

Abstract excerpt

Genotype-based algorithms that include VKORC1 and CYP2C9 genotypes are less predictive of warfarin dose variability in Africans as opposed to Europeans. Polymorphisms in GGCX, FPGS, or STX1B are associated with warfarin dose requirements in African-Americans. We sought to determine if they influenced warfarin dose in European-Americans, and another African population, specifically Egyptians. We genotyped 529...

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Identifiers

PMID: 26751406
DOI: 10.1111/cts.12385
PMCID: PMC4760888

Genes

FPGS
GGCX
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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