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Article

Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin.

Thrombosis and haemostasis - 1 Feb 2006

Vecsler Manuela, Loebstein Ronen, Almog Shlomo, Kurnik Daniel, Goldman Boleslav, Halkin Hillel, Gak Eva

Abstract excerpt

We examined the influence of combined genotypes on interindividual variability in warfarin dose-response. In 100 anticoagulated patients we quantified the effects of polymorphisms in: CYP2C9, VKORC1, calumenin (CALU), gamma-glutamyl carboxylase (GGCX) and microsomal epoxide hydrolase (EPHX1) on warfarin dose requirements. The G(1542)C VKORC1 polymorphism was associated with decreased warfarin doses in the hetero-...

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Source

Identifiers

PMID: 16493479
DOI: 10.1160/TH05-06-0446

Genes

CALU
VKORC1
EPHX1
GGCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin.PMID 16493479Read ↗

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