Article
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
Lancet (London, England) - 31 Aug 2013
Perera Minoli A, Cavallari Larisa H, Limdi Nita A, Gamazon Eric R, Konkashbaev Anuar, Daneshjou Roxana, Pluzhnikov Anna, Crawford Dana C, Wang Jelai, Liu Nianjun, Tatonetti Nicholas, Bourgeois Stephane, Takahashi Harumi, Bradford Yukiko, Burkley Benjamin M, Desnick Robert J, Halperin Jonathan L, Khalifa Sherief I, Langaee Taimour Y, Lubitz Steven A, Nutescu Edith A, Oetjens Matthew, Shahin Mohamed H, Patel Shitalben R, Sagreiya Hersh, Tector Matthew, Weck Karen E, Rieder Mark J, Scott Stuart A, Wu Alan H B, Burmester James K, Wadelius Mia, Deloukas Panos, Wagner Michael J, Mushiroda Taisei, Kubo Michiaki, Roden Dan M, Cox Nancy J, Altman Russ B, Klein Teri E, Nakamura Yusuke, Johnson Julie A
Abstract excerpt
BACKGROUND: VKORC1 and CYP2C9 are important contributors to warfarin dose variability, but explain less variability for individuals of African descent than for those of European or Asian descent. We aimed to identify additional variants contributing to warfarin dose requirements in African Americans. METHODS: We did a genome-wide association study of discovery and replication cohorts. Samples from...
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