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Article

The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans.

Clinical pharmacology and therapeutics - 1 Mar 2011

Perera M A, Gamazon E, Cavallari L H, Patel S R, Poindexter S, Kittles R A, Nicolae D, Cox N J

Abstract excerpt

It is well recognized that the genetic variants VKORC1-1639, CYP2C9*2, and CYP2C9*3 contribute to warfarin dose response. This has led to warfarin dosing algorithms that include these polymorphisms and explains between 47% and 56% of variability in dose in Caucasians. However, these polymorphisms explain significantly less of the variance in dose among African Americans. In order to identify novel variations that...

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Source

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Identifiers

PMID: 21270790
DOI: 10.1038/clpt.2010.322
PMCID: PMC3625373

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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