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Article

Does CALU SNP rs1043550 contribute variability to therapeutic warfarin dosing requirements?

Clinical medicine & research - 1 Jun 2013

Glurich Ingrid, Berg Richard L, Burmester James K

Abstract excerpt

OBJECTIVES: Calumenin, a molecular chaperone, exerts a regulatory effect on the vitamin K-dependent γ-carboxylation redox cycle that inhibits transfer of the reduced vitamin K from VKORC1, the pharmacological target of warfarin, to the γ-carboxylase. Because of its polymorphic structure and central role in the warfarin metabolic pathway, a contributory role for calumenin to warfarin dose variability has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23656803
DOI: 10.3121/cmr.2013.1130
PMCID: PMC3692386

Genes

CALU
VKORC1

Provenance

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