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Article

The concerted contribution of the S4-S5 linker and the S6 segment to the modulation of a Kv channel by 1-alkanols.

Molecular pharmacology - 1 Nov 2006

Bhattacharji Aditya, Kaplan Benjamin, Harris Thanawath, Qu Xiaoguang, Germann Markus W, Covarrubias Manuel

Abstract excerpt

Gating of voltage-gated K(+) channels (K(v) channels) depends on the electromechanical coupling between the voltage sensor and activation gate. The main activation gate of K(v) channels involves the COOH-terminal section of the S6 segment (S6-b) and the S4-S5 linker at the intracellular mouth of the pore. In this study, we have expanded our earlier work to probe the concerted contribution of these regions to the...

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Identifiers

PMID: 16887933
DOI: 10.1124/mol.106.026187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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