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Article

Acetylcholine and alcohol sensitivity of neuronal nicotinic acetylcholine receptors: mutations in transmembrane domains.

Alcoholism, clinical and experimental research - 1 Dec 2002

Borghese Cecilia M, Ali Deeba N, Bleck Virginia, Harris R Adron

Abstract excerpt

BACKGROUND: The effect of n-alcohols on glycine and gamma-aminobutyric acid type A receptors depends on two specific amino acids (AAs) located in the transmembrane domains (TM) 2 and 3. Our aim was to assess whether the corresponding AAs in the neuronal nicotinic acetylcholine receptor (nAChR) also formed a binding pocket for alcohols. METHODS: We made single AA substitutions in the homologous sites in rat...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12500099
DOI: 10.1097/01.ALC.0000042012.58231.D9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Acetylcholine and alcohol sensitivity of neuronal nicotinic acetylcholine receptors: mutations in transmembrane domains.PMID 12500099Read ↗

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