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Article

Nicotinic receptor pore mutations create a sensitive inhibitory site for ethanol.

Alcoholism, clinical and experimental research - 1 Sept 2000

Forman S A, Zhou Q

Abstract excerpt

BACKGROUND: Ethanol (EtOH) inhibition and enhancement of ligand-gated ion channel functions may be due to direct interactions with sites on these membrane proteins. Peripheral nicotinic receptors have pore sites that long-chain alcohols inhibit but EtOH does not, either because of weak binding (low affinity) or inability to impair ion translocation (low efficacy). We tested whether nicotinic pore mutations that...

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PMID: 11003201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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