Article

A unique lower X-gate in TASK channels traps inhibitors within the vestibule

2019-07-19

Abstract excerpt

TASK channels are unusual members of the two-pore domain potassium (K 2P ) channel family, with unique and unexplained physiological and pharmacological characteristics. TASKs are found in neurons 1,2 , cardiomyocytes 3–5 and vascular smooth muscle cells 6 where they are involved in regulation of heart rate 7 , pulmonary artery tone 6,8 , sleep/wake cycles 9 and responses to volatile anaesthetics 9–12 . K...

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Literature Corpus work: a6472a7f-0a5c-559f-bd6d-00c11d3d38a3
DOI: 10.1101/706168

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