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Article

What has been learnt from the thrombin-activatable fibrinolysis inhibitor-deficient mouse?

Journal of thrombosis and haemostasis : JTH - 1 May 2010

Morser J, Gabazza E C, Myles T, Leung L L K

Abstract excerpt

SUMMARY: Thrombin-activatable fibrinolysis inhibitor (TAFI) is a circulating zymogen that is activated physiologically by the thrombin/thrombomodulin complex to activated TAFI (TAFIa) which is a basic carboxypeptidase. Substrates include fibrin, leading to a reduction in rate of plasmin generation, and several proinflammatory mediators such as bradykinin, thrombin-cleaved osteopontin and complement factor C5a....

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Identifiers

PMID: 20128866
DOI: 10.1111/j.1538-7836.2010.03787.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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