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Article

Structure and function of the plasminogen/plasmin system.

Thrombosis and haemostasis - 1 Apr 2005

Castellino Francis J, Ploplis Victoria A

Abstract excerpt

Activation of the fibrinolytic system is dependent on the conversion of the plasma zymogen, plasminogen (Pg), to the serine protease plasmin (Pm) by the physiological activators urokinase-type Pg activator (uPA) or tissue-type plasminogen activator (tPA). The primary in vivo function of Pm is to regulate vascular patency by degrading fibrin-containing thrombi. However, the identification of Pg/Pm receptors and...

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Identifiers

PMID: 15841308
DOI: 10.1160/TH04-12-0842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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