Article
Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions.
PloS one - 1 Jan 2017
Tashima Yuko, Banno Fumiaki, Kita Toshiyuki, Matsuda Yasuyuki, Yanamoto Hiroji, Miyata Toshiyuki
Abstract excerpt
Plasminogen (Plg) is a precursor of plasmin that degrades fibrin. A race-specific A620T mutation in Plg, also known as Plg-Tochigi, originally identified in a patient with recurrent venous thromboembolism, causes dysplasminogenemia with reduced plasmin activity. The Plg-A620T mutation is present in 3-4% of individuals in East Asian populations, and as many as 50,000 Japanese are estimated to be homozygous for the...
Topics
- Amino Acid Substitution
- Animals
- Brain Ischemia
- Conjunctivitis
- Disease Models, Animal
- Female
- Fibrin
- Fibrinolysin
- Gene Expression
- Gene Knock-In Techniques
- Humans
- Male
- Mice
- Mice, Transgenic