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Article

Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions.

PloS one - 1 Jan 2017

Tashima Yuko, Banno Fumiaki, Kita Toshiyuki, Matsuda Yasuyuki, Yanamoto Hiroji, Miyata Toshiyuki

Abstract excerpt

Plasminogen (Plg) is a precursor of plasmin that degrades fibrin. A race-specific A620T mutation in Plg, also known as Plg-Tochigi, originally identified in a patient with recurrent venous thromboembolism, causes dysplasminogenemia with reduced plasmin activity. The Plg-A620T mutation is present in 3-4% of individuals in East Asian populations, and as many as 50,000 Japanese are estimated to be homozygous for the...

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Identifiers

PMID: 28686706
DOI: 10.1371/journal.pone.0180981
PMCID: PMC5501636

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Source receipt: pubmed, retrieved 7 Sept 2026.

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