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Article

Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo.

Blood - 1 Mar 2007

Nishimura Toshihiko, Myles Timothy, Piliponsky Adrian M, Piliposky Adrian M, Kao Peter N, Berry Gerald J, Leung Lawrence L K

Abstract excerpt

Plasma procarboxypeptidase B (proCPB) is activated by the endothelial thrombin-thrombomodulin [corrected] complex. Activated proCPB [corrected] (CPB) functions as a fibrinolysis inhibitor, but it may play a broader role by inactivating inflammatory mediators. To test this hypothesis, C5a-induced alveolitis was studied in wild-type (WT) and proCPB-deficient mice (proCPB-/-). C5a-induced alveolitis, as measured by...

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Identifiers

PMID: 17105819
DOI: 10.1182/blood-2006-03-012567
PMCID: PMC1801069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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