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Article

Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life.

The Journal of clinical investigation - 1 Jan 2002

Nagashima Mariko, Yin Zheng-Feng, Zhao Lei, White Kathy, Zhu Yanhong, Lasky Nina, Halks-Miller Meredith, Broze George J, Fay William P, Morser John

Abstract excerpt

To investigate the consequence of deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI), we generated homozygous TAFI-deficient mice by targeted gene disruption. Intercrossing of heterozygous TAFI mice produced offspring in the expected Mendelian ratio, indicating that transmission of the mutant TAFI allele did not lead to embryonic lethality. TAFI-deficient mice developed normally, reached adulthood,...

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Identifiers

PMID: 11781355
DOI: 10.1172/JCI12119
PMCID: PMC150816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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