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Article

Structure-function relationships in thrombin-activatable fibrinolysis inhibitor.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2016

Plug T, Meijers J C M

Abstract excerpt

Thrombin-activatable fibrinolysis inhibitor (TAFI) is an important regulator in the balance of coagulation and fibrinolysis. TAFI is a metallocarboxypeptidase that circulates in plasma as zymogen. Activated TAFI (TAFIa) cleaves C-terminal lysine or arginine residues from peptide substrates. The removal of C-terminal lysine residues from partially degraded fibrin leads to reduced plasmin formation and thus...

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Identifiers

PMID: 26786060
DOI: 10.1111/jth.13261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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