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Article

New insights into the biology of tissue factor pathway inhibitor.

Journal of thrombosis and haemostasis : JTH - 1 Jun 2015

Maroney S A, Mast A E

Abstract excerpt

Tissue factor pathway inhibitor (TFPI) dampens the initiation of blood coagulation by inhibiting two potent procoagulant complexes, tissue factor-factor VIIa (TF-FVIIa) and early forms of prothrombinase. TFPI isoforms, TFPIα and TFPIβ, result from alternative splicing of mRNA, producing distinct C-terminal ends of the two proteins. Both isoforms inhibit TF-FVIIa, but only TFPIα can inhibit early forms of...

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Identifiers

PMID: 26149025
DOI: 10.1111/jth.12897
PMCID: PMC4604745

Genes

TFPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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