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Article

Distinct Activities of Exonuclease 1 and Flap Endonuclease 1 at Telomeric G4 DNA

25 Jan 2010

Abstract excerpt

BACKGROUND: Exonuclease 1 (EXO1) and Flap endonuclease 1 (FEN1) are members of the RAD2 family of structure-specific nucleases. Genetic analysis has identified roles for EXO1 and FEN1 in replication, recombination, DNA repair and maintenance of telomeres. Telomeres are composed of G-rich repeats that readily form G4 DNA. We recently showed that human EXO1 and FEN1 exhibit distinct activities on G4 DNA substrates...

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PMID: 20126648
DOI: 10.1371/journal.pone.0008908

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