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Article

Exonuclease 1 and its versatile roles in DNA repair.

Critical reviews in biochemistry and molecular biology - 1 Jan 2000

Keijzers Guido, Liu Dekang, Rasmussen Lene Juel

Abstract excerpt

Exonuclease 1 (EXO1) is a multifunctional 5' → 3' exonuclease and a DNA structure-specific DNA endonuclease. EXO1 plays roles in DNA replication, DNA mismatch repair (MMR) and DNA double-stranded break repair (DSBR) in lower and higher eukaryotes and contributes to meiosis, immunoglobulin maturation, and micro-mediated end-joining in higher eukaryotes. In human cells, EXO1 is also thought to play a role in...

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Aging
DNA Breaks
DNA Repair
Exodeoxyribonucleases
Meiosis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Processing, Post-Translational

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Identifiers

PMID: 27494243
DOI: 10.1080/10409238.2016.1215407

Genes

EXO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Exonuclease 1 and its versatile roles in DNA repair.PMID 27494243Read ↗

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Exonuclease 1 (Exo1) Participates in Mammalian Non-Homologous End Joining and Contributes to Drug Resistance in Ovarian CancerSemantic proximity Read ↗

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Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in <i> Exo1 <sup>D173A</sup> </i> miceSemantic proximity Read ↗

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A miceSemantic proximity Read ↗

The significance of Exo1 K589E polymorphism on cancer susceptibility: evidence based on a meta-analysis.Semantic proximity Read ↗

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Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.Semantic proximity Read ↗

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