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Article

The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.

Nucleic acids research - 1 Jan 2006

Liu Ren, Qiu Junzhuan, Finger L David, Zheng Li, Shen Binghui

Abstract excerpt

Flap endonuclease-1 (FEN-1) is a structure-specific nuclease best known for its involvement in RNA primer removal and long-patch base excision repair. This enzyme is known to possess 5'-flap endo- (FEN) and 5'-3' exo- (EXO) nuclease activities. Recently, FEN-1 has been reported to also possess a gap endonuclease (GEN) activity, which is possibly involved in apoptotic DNA fragmentation and the resolution of...

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Identifiers

PMID: 16582103
DOI: 10.1093/nar/gkl106
PMCID: PMC1421507

Genes

WRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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