Article

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in <i> Exo1 <sup>D173A</sup> </i> mice

2021-10-05

Abstract excerpt

<h4>ABSTRACT</h4> DNA damage response pathways rely extensively on nuclease activity to process DNA intermediates. Exonuclease 1 (EXO1) is a pleiotropic evolutionary conserved DNA exonuclease involved in various DNA repair pathways, replication, antibody diversification, and meiosis. But, whether EXO1 facilitates these DNA metabolic processes through its enzymatic or scaffolding functions remains unclear. Here we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 114557eb-65c6-5c9a-bd3c-6fe38bb86ca5
DOI: 10.1101/2021.10.05.463200

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in <i> Exo1 <sup>D173A</sup> </i> miceDOI 10.1101/2021.10.05.463200Read

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A miceSemantic proximity Read

Exonuclease 1 and its versatile roles in DNA repair.Semantic proximity Read

Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility.Semantic proximity Read

EXO1-A multi-tasking eukaryotic nuclease.Semantic proximity Read

Identification of EXO1 as a potential biomarker associated with prognosis and tumor immune microenvironment for specific human cancers.Semantic proximity Read

Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae.Semantic proximity Read

A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.Semantic proximity Read

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Semantic proximity Read

EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.Semantic proximity Read

The Human Exonuclease-1 Interactome And Phosphorylation SitesSemantic proximity Read

Exonuclease 1-dependent and independent mismatch repair.Semantic proximity Read

Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in CancerSemantic proximity Read