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Article

EXO1-A multi-tasking eukaryotic nuclease.

DNA repair - 2 Dec 2004

Tran Phuoc T, Erdeniz Naz, Symington Lorraine S, Liskay R Michael

Abstract excerpt

Exo1 was first isolated as a 5' --> 3' exonuclease activity induced during meiosis in fission yeast and since that time has been implicated in a multitude of eukaryotic DNA metabolic pathways that include DNA repair, recombination, replication, and telomere integrity. Involvement in multiple pathways affecting genomic stability makes EXO1 a logical target for mutation during oncogenesis. Here, we review studies...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15474417
DOI: 10.1016/j.dnarep.2004.05.015

Genes

EXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EXO1-A multi-tasking eukaryotic nuclease.PMID 15474417Read ↗

Exonuclease 1 and its versatile roles in DNA repair.Semantic proximity Read ↗

Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in CancerSemantic proximity Read ↗

Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A miceSemantic proximity Read ↗

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in <i> Exo1 <sup>D173A</sup> </i> miceSemantic proximity Read ↗

Requirement of S. pombe exonuclease II, a homologue of S. cerevisiae Sep1, for normal mitotic growth and viability.Semantic proximity Read ↗

A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.Semantic proximity Read ↗

Exonuclease 1-dependent and independent mismatch repair.Semantic proximity Read ↗

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Semantic proximity Read ↗

The Human Exonuclease-1 Interactome And Phosphorylation SitesSemantic proximity Read ↗

Identification and characterization of <i>Saccharomyces cerevisiae EXO1</i> , a gene encoding an exonuclease that interacts with MSH2Semantic proximity Read ↗

Exonuclease 1 (Exo1) Participates in Mammalian Non-Homologous End Joining and Contributes to Drug Resistance in Ovarian CancerSemantic proximity Read ↗

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