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Article

Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.

Gastroenterology - 1 Feb 2009

Leedham Simon J, Graham Trevor A, Oukrif Dahmane, McDonald Stuart A C, Rodriguez-Justo Manuel, Harrison Rebecca F, Shepherd Neil A, Novelli Marco R, Jankowski Janusz A Z, Wright Nicholas A

Abstract excerpt

BACKGROUND & AIMS: The clonality of colitis-associated neoplasia has not been fully determined. One previous report showed polyclonal origins with subsequent monoclonal outgrowth. We aimed to assess the clonality and mutation burden of individual crypts in colitis-associated neoplasias to try to identify gatekeeping founder mutations, and explore the clonality of synchronous lesions to look for field effects....

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PMID: 19103203
DOI: 10.1053/j.gastro.2008.10.086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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