Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jul 2013

Humphries Adam, Cereser Biancastella, Gay Laura J, Miller Daniel S J, Das Bibek, Gutteridge Alice, Elia George, Nye Emma, Jeffery Rosemary, Poulsom Richard, Novelli Marco R, Rodriguez-Justo Manuel, McDonald Stuart A C, Wright Nicholas A, Graham Trevor A

Abstract excerpt

The genetic and morphological development of colorectal cancer is a paradigm for tumorigenesis. However, the dynamics of clonal evolution underpinning carcinogenesis remain poorly understood. Here we identify multipotential stem cells within human colorectal adenomas and use methylation patterns of nonexpressed genes to characterize clonal evolution. Numerous individual crypts from six colonic adenomas and a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clone Cells

Share to Colorectal Neoplasms

Share to DNA, Neoplasm

Share to Epigenesis, Genetic

Share to Multipotent Stem Cells

Share to Neoplastic Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 23766371
DOI: 10.1073/pnas.1220353110
PMCID: PMC3704042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.PMID 23766371Read ↗

Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture.Semantic proximity Read ↗

Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations.Semantic proximity Read ↗

Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers.Semantic proximity Read ↗

Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.Semantic proximity Read ↗

Quantification of crypt and stem cell evolution in the normal and neoplastic human colon.Semantic proximity Read ↗

Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor.Semantic proximity Read ↗

Clonal expansion in the human gut: mitochondrial DNA mutations show us the way.Semantic proximity Read ↗

Investigating the fixation and spread of mutations in the gastrointestinal epithelium.Semantic proximity Read ↗

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixtureSemantic proximity Read ↗

Many colorectal cancers are "flat" clonal expansions.Semantic proximity Read ↗

Quantifying intestinal stem cell dynamics using microsatellite sequencingSemantic proximity Read ↗

Intra-tumour diversification in colorectal cancer at the single-cell level.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.